Oligonucleotide Therapeutics (ASO/siRNA)

Cat. No.: A51277

CAS No.: 153021-75-1

Trecovirsen

Synonyms: GEM91

Trecovirsen is an antiviral agent that targets HIV gag mRNA by hybridizing with its complementary sequence at the initiation site. This interaction leads to the induction of a reversible, dose-dependent prolongation of activated partial thromboplastin time due to its polyanionic properties. Trecovirsen is applicable for research on HIV infection, providing insights into the mechanisms of viral replication and potential therapeutic strategies.

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Cat. No.: A68428

CAS No.: 2415330-05-9

Zorevunersen sodium

Synonyms: STK-001 sodium

Zorevunersen sodium is an antisense oligonucleotide that acts as an activator of the Scn1a gene through TANGO technology. This compound enhances Scn1a mRNA transcripts, leading to increased expression of the NaV1.1 protein. By restoring the excitability of parvalbumin interneurons, Zorevunersen sodium effectively reduces seizure frequency and improves survival in mouse models. It is a valuable tool for research focused on Dravet syndrome and related epileptic disorders.

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1 mg

$225.00

5 mg

$580.00

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Cat. No.: A68669

CAS No.: 2415330-04-8

Zorevunersen

Synonyms: STK-001

Zorevunersen is an antisense oligonucleotide that acts as an activator of the Scn1a gene through TANGO technology. It enhances the production of Scn1a mRNA transcripts, leading to an increased expression of the NaV1.1 protein. This compound has demonstrated the ability to restore the excitability of parvalbumin interneurons, effectively reducing seizure activity and improving survival rates in murine models. Zorevunersen is a valuable tool for research focused on Dravet syndrome and related channelopathies.

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