Fig. 1 · Structure
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OYYF-175
Antimicrobial Antifolate
OYYF-175 is an antimicrobial antifolate that acts as a potent inhibitor of dihydrofolate reductase (DHFR), demonstrating an IC50 of 2.36 nM against Escherichia coli DHFR. This compound exhibits broad-spectrum antibacterial activity, particularly effective against multi-drug resistant Gram-negative strains. OYYF-175 can be utilized in research focused on antibiotic resistance and the development of novel antimicrobial agents.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 65829-22-3 |
| Applications | Antimicrobial Antifolate |
| Formula | C17H14FN5 |
| Molecular Weight | 307.32 |
| SMILES | NC1=C2C3=C(N(CC4=CC=CC=C4F)C=C3)C=CC2=NC(N)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.