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pan-KRAS-IN-15

Catalog No.: A63623
pan-KRAS Inhibitor
pan-KRAS-IN-15 is a pan-KRAS inhibitor that targets multiple KRAS mutant variants. This compound exhibits potent inhibitory activity against KRAS-driven signaling pathways, making it valuable for studying the mechanisms of KRAS-related cancers. It is particularly relevant for research focused on pancreatic cancer, providing insights into therapeutic strategies and disease progression.
pan-KRAS-IN-15 3034052-52-0 pan-KRAS Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Descriptionpan-KRAS-IN-15 is a pan-KRAS inhibitor that targets multiple KRAS mutant variants. This compound exhibits potent inhibitory activity against KRAS-driven signaling pathways, making it valuable for studying the mechanisms of KRAS-related cancers. It is particularly relevant for research focused on pancreatic cancer, providing insights into therapeutic strategies and disease progression.
Product Information
Catalog NumA63623
FormulaC36H37F3N6O2
Molecular Weight642.71
CAS Number3034052-52-0
SMILESCC#CC1=C2C(N3C[C@@H](CC4)N[C@@H]4C3)=NC(OC[C@@]56CCCN5C[C@@H](C6)F)=NC2=C(C(C7=CC(O)=CC8=C7C(CC)=C(C=C8)F)=N1)F
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Cell Cycle > Ras