Fig. 1 · Structure

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PAT-347 sodium

ATX Inhibitor

PAT-347 sodium is a selective inhibitor of Autotaxin (ATX), an enzyme that hydrolyzes lysophosphatidylcholine (LPC) and regulates the production of lysophosphatidic acid (LPA) in the bloodstream. By targeting ATX, PAT-347 sodium is instrumental in research focused on modulating LPA signaling pathways, which are implicated in various pathological conditions such as cancer, inflammation, and fibrosis. This compound serves as a valuable tool for understanding the role of lysophospholipids in cellular processes and disease mechanisms.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 2650082-35-0
Applications ATX Inhibitor
Formula C28H20ClF2N2NaO3S
Molecular Weight 560.97
SMILES
O=C(C1=C(F)C(SC2=C(C)N(CC(N3C4=C(C5(CC5)C3)C=CC=C4)=O)C6=C2C=CC(Cl)=C6F)=CC=C1)O[Na]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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