Patrinoside aglucone is an iridoid glucoside isolated from Valeriana tuberosa, exhibiting significant anticancer properties through G2/M phase tumor cell cycle arrest and apoptosis induction. This compound effectively inhibits the proliferation of cancer stem cells, such as MDA-MB-231 and U-251MG. Additionally, Patrinoside aglucone demonstrates potent anti-inflammatory activity, as evidenced by its ability to inhibit nitric oxide release (IC50: 43.44 μM) and reduce levels of pro-inflammatory cytokines including TNF-α, IL-1β, IL-6, PGE2, and COX-2.
Patrinoside aglucone is an iridoid glucoside isolated from Valeriana tuberosa, exhibiting significant anticancer properties through G2/M phase tumor cell cycle arrest and apoptosis induction. This compound effectively inhibits the proliferation of cancer stem cells, such as MDA-MB-231 and U-251MG. Additionally, Patrinoside aglucone demonstrates potent anti-inflammatory activity, as evidenced by its ability to inhibit nitric oxide release (IC50: 43.44 μM) and reduce levels of pro-inflammatory cytokines including TNF-α, IL-1β, IL-6, PGE2, and COX-2.
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