PET-cGMP is a cyclic guanosine monophosphate analog that selectively activates protein kinase G (PKG) I, with an EC50 of 3.8 nM for the PKG Iβ isoform and 193 nM for PKG II. Its potent agonistic properties make it a valuable tool in studying signaling pathways involving PKG I, particularly in cardiovascular and neuronal research. Researchers can utilize PET-cGMP to elucidate the roles of cGMP signaling in various physiological and pathological contexts.
PET-cGMP is a cyclic guanosine monophosphate analog that selectively activates protein kinase G (PKG) I, with an EC50 of 3.8 nM for the PKG Iβ isoform and 193 nM for PKG II. Its potent agonistic properties make it a valuable tool in studying signaling pathways involving PKG I, particularly in cardiovascular and neuronal research. Researchers can utilize PET-cGMP to elucidate the roles of cGMP signaling in various physiological and pathological contexts.
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