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Biological Activity
PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC50 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively.
Targets
| LRRK2 | G2019S LRRK2 | |||
| 3nM | 11nM |
| In vitro | DMSO | 56 mg/mL (183.4 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.75 mL | 163.76 mL | 327.51 mL |
| 0.5 mM | 6.55 mL | 32.75 mL | 65.5 mL |
| 1 mM | 3.28 mL | 16.38 mL | 32.75 mL |
| 5 mM | 0.66 mL | 3.28 mL | 6.55 mL |
*The above data is based on the productmolecular weight 305.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15504 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1527473-33-1 |
| Formula | C17H15N5O |
| M. Wt | 305.33 |
| Purity | >98% |
| Synonyms | PF06447475, PF 06447475 |
| SMILES | C1COCCN1C2=NC=NC3=C2C(=CN3)C4=CC=CC(=C4)C#N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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