PF-06447475

Catalog No.: A15504

LRRK2 inhibitor

PF-06447475

PF-06447475 Chemical Structure

CAS NO. 1527473-33-1

PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC50 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $100.00

Special Price $90.00

25 mg

Regular Price: $200.00

Special Price $180.00

50 mg

Regular Price: $400.00

Special Price $360.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC50 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively.
Targets
LRRK2 G2019S LRRK2
3nM11nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.75 mL 163.76 mL 327.51 mL
0.5 mM 6.55 mL 32.75 mL 65.5 mL
1 mM 3.28 mL 16.38 mL 32.75 mL
5 mM 0.66 mL 3.28 mL 6.55 mL

*The above data is based on the productmolecular weight 305.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15504
Actions Inhibitor
M. Wt 305.33
Formula C17H15N5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1527473-33-1
Synonyms PF06447475, PF 06447475
SMILES C1COCCN1C2=NC=NC3=C2C(=CN3)C4=CC=CC(=C4)C#N

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