PF-06840003 is a highly selective orally bioavailable IDO-1 inhibitor with IC50s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively.
PF-06840003 is a highly selective orally bioavailable IDO-1 inhibitor with IC50s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively.
Targets
Target
Value
Cell Research
Cell Line
Type
Value
Description
References
Product Information
Catalog Num
A20807
Formula
C12H9FN2O2
Molecular Weight
232.21
CAS Number
198474-05-4
SMILES
O=C(C(C1=CNC2=C1C=C(F)C=C2)C3)NC3=O
Synonyms
PF06840003, PF 06840003; EOS200271, EOS 200271, EOS-200271
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro
DMSO
40 mg/mL (172.25 mM)
Water
Insoluble
Ethanol
5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula: