PF-8380

Catalog No.: A11527

Autotaxin inhibitor

PF-8380

PF-8380 Chemical Structure

CAS NO. 1144035-53-9

PF-8380 is a potent and specific autotaxin inhibitor with an IC50 value of 2.8 nM.

Availability: In stock

Package Price Qty
5 mg
$55.00
10 mg
$80.00
25 mg
$150.00
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Biological Activity

PF-8380 is a potent and specific autotaxin inhibitor with an IC50 value of 2.8 nM.
Targets
Autotaxin
2.8 nM
In vitro (25°C) DMSO 89 mg/mL (186.06 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1%cmc-na 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.91 mL 104.53 mL 209.06 mL
0.5 mM 4.18 mL 20.91 mL 41.81 mL
1 mM 2.09 mL 10.45 mL 20.91 mL
5 mM 0.42 mL 2.09 mL 4.18 mL

*The above data is based on the productmolecular weight 478.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11527
Actions Inhibitor
CAS No. 1144035-53-9
Formula C22H21Cl2N3O5
M. Wt 478.33
Purity >98%
Synonyms PF 8380, PF8380
SMILES C1CN(CCN1CCC(=O)C2=CC3=C(C=C2)NC(=O)O3)C(=O)OCC4=CC(=CC(=C4)Cl)Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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