PhAc-ALGP-Dox is a peptide-drug conjugate designed for targeted anticancer therapy. This prodrug demonstrates significant cytotoxic activity against triple-negative breast cancer (TNBC) cell lines, with IC50 values ranging from 311 nM to 34.25 μM for E0771, MDA-MB-231, and MDA-MB-468, as well as exhibiting effects on colorectal carcinoma (CrC) cells (LS 174T) and normal epithelial cells. Its unique mechanism allows for selective delivery of doxorubicin, making it a valuable tool for research applications focused on improving chemotherapy efficacy and reducing off-target effects in cancer treatment.
PhAc-ALGP-Dox is a peptide-drug conjugate designed for targeted anticancer therapy. This prodrug demonstrates significant cytotoxic activity against triple-negative breast cancer (TNBC) cell lines, with IC50 values ranging from 311 nM to 34.25 μM for E0771, MDA-MB-231, and MDA-MB-468, as well as exhibiting effects on colorectal carcinoma (CrC) cells (LS 174T) and normal epithelial cells. Its unique mechanism allows for selective delivery of doxorubicin, making it a valuable tool for research applications focused on improving chemotherapy efficacy and reducing off-target effects in cancer treatment.
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