Polyphemusin II

Catalog No.: A49175
Antimicrobial Peptide
Polyphemusin II is an antimicrobial peptide derived from the hemocytes of Limulus polyphemus. It demonstrates potent antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria, as well as fungal species. This compound is valuable for research applications focusing on antimicrobial mechanisms and the development of new therapeutics targeting infectious agents.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPolyphemusin II is an antimicrobial peptide derived from the hemocytes of Limulus polyphemus. It demonstrates potent antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria, as well as fungal species. This compound is valuable for research applications focusing on antimicrobial mechanisms and the development of new therapeutics targeting infectious agents.
Product Information
Catalog NumA49175
FormulaC108H161N37O20S4
Molecular Weight2425.93
CAS Number125139-68-6
SequenceArg-Arg-Trp-Cys-Phe-Arg-Val-Cys-Tyr-Lys-Gly-Phe-Cys-Tyr-Arg-Lys-Cys-Arg-NH2 (Disulfide bridge: Cys4-Cys17,Cys8-Cys13)
Sequence shorteningRRWCFRVCYKGFCYRKCR-NH2 (Disulfide bridge: Cys4-Cys17,Cys8-Cys13)
SMILESC([C@@H](C(N[C@@H]1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@]3(C(=O)N[C@@H](CC4=CC=C(O)C=C4)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@](CSSC3)(C(=O)N[C@@H](CC6=CC=C(O)C=C6)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)CSSC1)[H])[H])=O)NC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CCCNC(=N)N)=O)C=7C=8C(NC7)=CC=CC8
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