Polyporenic acid C is a lanostane-type triterpenoid that functions as an apoptosis inducer. Isolated from Poria cocos, this compound activates key apoptotic pathways by cleaving caspase-8, caspase-3, and PARP, while modulating the phosphorylation status of Akt, PTEN, and p53. Additionally, Polyporenic acid C enhances JNK activation and exhibits significant anticancer activity against non-small cell lung cancer. This makes it a valuable reagent for research into cancer therapies and apoptotic mechanisms.
Polyporenic acid C is a lanostane-type triterpenoid that functions as an apoptosis inducer. Isolated from Poria cocos, this compound activates key apoptotic pathways by cleaving caspase-8, caspase-3, and PARP, while modulating the phosphorylation status of Akt, PTEN, and p53. Additionally, Polyporenic acid C enhances JNK activation and exhibits significant anticancer activity against non-small cell lung cancer. This makes it a valuable reagent for research into cancer therapies and apoptotic mechanisms.
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