PRMT5-IN-19 is a selective non-nucleoside inhibitor of protein arginine methyltransferase 5 (PRMT5), demonstrating IC50 values of 23.9 nM in radioactive biochemical assays and 47 nM in AlphaLISA assays. This compound effectively occupies the SAM-binding pocket of PRMT5, inhibiting its methyltransferase activity with notable selectivity for PRMT5 over other PRMTs and protein lysine methyltransferases (PKMTs). PRMT5-IN-19 has been shown to inhibit cell proliferation through the induction of apoptosis, making it useful for research in cancer biology and therapeutic development.
PRMT5-IN-19 is a selective non-nucleoside inhibitor of protein arginine methyltransferase 5 (PRMT5), demonstrating IC50 values of 23.9 nM in radioactive biochemical assays and 47 nM in AlphaLISA assays. This compound effectively occupies the SAM-binding pocket of PRMT5, inhibiting its methyltransferase activity with notable selectivity for PRMT5 over other PRMTs and protein lysine methyltransferases (PKMTs). PRMT5-IN-19 has been shown to inhibit cell proliferation through the induction of apoptosis, making it useful for research in cancer biology and therapeutic development.
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