PRMT5-MTA-IN-8 is a potent inhibitor of the PRMT5-MTA complex, with an IC50 value of 4.4 nM. This compound effectively reduces the intracellular levels of symmetric dimethylarginine (SDMA) and inhibits the proliferation of MTAP-deficient cells. Research has demonstrated its antitumor activity, particularly in mouse models of triple-negative breast cancer, by promoting tumor cell apoptosis through PRMT5 inhibition. PRMT5-MTA-IN-8 is suitable for investigations into cancer biology and therapeutic strategies targeting PRMT5-related pathways.
PRMT5-MTA-IN-8 is a potent inhibitor of the PRMT5-MTA complex, with an IC50 value of 4.4 nM. This compound effectively reduces the intracellular levels of symmetric dimethylarginine (SDMA) and inhibits the proliferation of MTAP-deficient cells. Research has demonstrated its antitumor activity, particularly in mouse models of triple-negative breast cancer, by promoting tumor cell apoptosis through PRMT5 inhibition. PRMT5-MTA-IN-8 is suitable for investigations into cancer biology and therapeutic strategies targeting PRMT5-related pathways.
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