PROTAC BRD4 Degrader-15 is a proteolysis-targeting chimera (PROTAC) that utilizes ligands for von Hippel-Lindau (VHL) and BRD4, exhibiting IC50 values of 7.2 nM for the BRD4 BD1 domain and 8.1 nM for the BD2 domain. This compound effectively induces the degradation of the BRD4 protein in PC3 prostate cancer cells. Its ability to selectively target and eliminate BRD4 makes it a valuable tool for research in cancer biology and therapeutic applications aimed at modulating gene expression.
PROTAC BRD4 Degrader-15 is a proteolysis-targeting chimera (PROTAC) that utilizes ligands for von Hippel-Lindau (VHL) and BRD4, exhibiting IC50 values of 7.2 nM for the BRD4 BD1 domain and 8.1 nM for the BD2 domain. This compound effectively induces the degradation of the BRD4 protein in PC3 prostate cancer cells. Its ability to selectively target and eliminate BRD4 makes it a valuable tool for research in cancer biology and therapeutic applications aimed at modulating gene expression.
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