BRD4 D1-IN-2 is a selective inhibitor targeting BRD4 D1, exhibiting a potent IC50 of less than 0.092 µM. With an affinity of 15 nM for BRD4 D1, this compound demonstrates over 500-fold selectivity against both BRD2 D1 and BRD4 D2, as determined by isothermal titration calorimetry (ITC). BRD4 D1-IN-2 is valuable for research applications exploring the role of BRD4 in epigenetic regulation and its implications in cancer and other diseases.
BRD4 D1-IN-2 is a selective inhibitor targeting BRD4 D1, exhibiting a potent IC50 of less than 0.092 µM. With an affinity of 15 nM for BRD4 D1, this compound demonstrates over 500-fold selectivity against both BRD2 D1 and BRD4 D2, as determined by isothermal titration calorimetry (ITC). BRD4 D1-IN-2 is valuable for research applications exploring the role of BRD4 in epigenetic regulation and its implications in cancer and other diseases.
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