(S)-GNE-987 is a selective PROTAC BRD4 degrader that functions by abrogating binding to von Hippel-Lindau while maintaining specific interactions with BRD4 bromodomains. With IC50 values of 4 nM for BD1 and 3.9 nM for BD2, (S)-GNE-987 facilitates targeted degradation of BRD4, making it a valuable tool in research focused on epigenetic regulation and cancer therapy. Additionally, it can be instrumental in the design of PROTAC-Antibody Conjugates (PAC) for enhanced therapeutic applications.
(S)-GNE-987 is a selective PROTAC BRD4 degrader that functions by abrogating binding to von Hippel-Lindau while maintaining specific interactions with BRD4 bromodomains. With IC50 values of 4 nM for BD1 and 3.9 nM for BD2, (S)-GNE-987 facilitates targeted degradation of BRD4, making it a valuable tool in research focused on epigenetic regulation and cancer therapy. Additionally, it can be instrumental in the design of PROTAC-Antibody Conjugates (PAC) for enhanced therapeutic applications.
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