PROTAC SMARCA2 degrader-31

Catalog No.: A40464
SMARCA2 Degrader
PROTAC SMARCA2 degrader-31 is a targeted degrader of the SMARCA2 protein, utilizing a proteolysis-targeting chimera (PROTAC) approach. This compound has demonstrated an impressive degradation rate of up to 99% in H929 cells at a concentration of 100 nM. It exhibits significant anti-proliferative activity, making it a valuable tool for cancer research and investigations into SMARCA2-related pathways.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPROTAC SMARCA2 degrader-31 is a targeted degrader of the SMARCA2 protein, utilizing a proteolysis-targeting chimera (PROTAC) approach. This compound has demonstrated an impressive degradation rate of up to 99% in H929 cells at a concentration of 100 nM. It exhibits significant anti-proliferative activity, making it a valuable tool for cancer research and investigations into SMARCA2-related pathways.
Product Information
Catalog NumA40464
FormulaC48H65N9O6S
Molecular Weight896.15
CAS Number2380274-45-1
SMILESOC1=C(C2=CC(N3CCN(C(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)C[C@@H](O)C4)=O)=O)=O)CC3)=C(N)N=N2)C=CC=C1
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