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Carboxypeptidases

Carboxypeptidase inhibitors target exopeptidases that trim the C-terminal residue from peptides and proteins. Most compounds here target glutamate carboxypeptidase II (GCPII), also called N-acetylated alpha-linked acidic dipeptidase (NAALADase). The enzyme cleaves the neuropeptide N-acetylaspartylglutamate (NAAG) into N-acetylaspartate and glutamate. A 1999 study reported that selective NAALADase inhibition with PMPA reduced ischemic brain injury in an animal model. The thiol-based inhibitor 2-MPPA was described in 2003 as an orally active GCPII inhibitor. ZJ 43 is a urea-based compound that inhibits both GCPII and the related glutamate carboxypeptidase III (GCPIII). The set also holds Histargin, a carboxypeptidase B inhibitor, and a carboxypeptidase G2 (CPG2) inhibitor for the bacterial folate-cleaving enzyme.

7 Items

  • CPA inhibitor
    Cat. No.
    A11369
    CAS No.
    223532-02-3

    CPA inhibitor

    Synonyms: Carboxypeptidase inhibitor

    CPA inhibitor is a potent inhibitor for carboxypeptidase A (CPA).

    In stock View Details
    1 mg
    $45.00
    5 mg
    $120.00
    All 7 sizes
  • 2-MPPA
    Cat. No.
    A12809
    CAS No.
    254737-29-6

    2-MPPA

    2-MPPA is a selective glutamate carboxypeptidase II (GCP-II) inhibitor used in the treatment of neurological disorders associated with excessive activation of glutamatergic systems. Attenuates glutamate transmission resulting in the relief of neuropathic pain.

    In stock View Details
    1 mg
    $40.00
    5 mg
    $105.00
    All 8 sizes
  • PMPA
    Cat. No.
    A15310
    CAS No.
    173039-10-6

    PMPA

    PMPA is a potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase (NAALADase), which is a membrane-bound peptidase that hydrolyses N-acetyl-L-aspartate-L-glutamate (NAAG), a major brain peptide.

    In stock View Details
    5 mg
    $55.00
    10 mg
    $85.00
    All 5 sizes
  • ZJ 43
    Cat. No.
    A15318
    CAS No.
    723331-20-2

    ZJ 43

    ZJ 43 is a potent inhibitor of PSM and PSMAL (glutamate carboxypeptidase II and III).

    In stock View Details
    1 mg
    $85.00
    10 mg
    $205.00
    All 2 sizes
  • Mergetpa
    Cat. No.
    A69589
    CAS No.
    77102-28-4

    Mergetpa

    Mergetpa is a potent carboxypeptidase inhibitor that selectively blocks the conversion of kinins and B2 receptor antagonists into metabolites devoid of the C-terminal arginine. This activity plays a crucial role in modulating kinin signaling pathways, making it valuable for research in cardiovascular and inflammatory diseases. Mergetpa can serve as a tool for studying the physiological effects of kinin peptides and their potential therapeutic applications.

    In stock View Details
    5 mg
    $230.00
    10 mg
    $375.00
    All 5 sizes
  • Histargin
    Cat. No.
    A69601
    CAS No.
    93361-66-1

    Histargin

    Histargin is a selective inhibitor of carboxypeptidase B, exhibiting an IC50 of 17 μg/ml. It demonstrates minimal inhibitory activity against carboxypeptidase A, with an IC50 greater than 100 μg/ml. This compound is useful in research applications involving protein metabolism and regulation, facilitating the study of carboxypeptidase-related processes in various biological systems. Histargin is derived from actinomycetes, adding to its relevance in natural product research.

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    Out of stock

    All 3 sizes

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