Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Matrix metalloproteinase (MMP) inhibitors block zinc endopeptidases that degrade collagen and other matrix proteins. The first such activity, a collagenase, was detected in amphibian tissue culture in 1962. MMPs remodel tissue during development and wound repair, and they help tumor cells invade surrounding matrix. Membrane type 1 MMP (MT1-MMP, MMP-14), described in 1994, is anchored on the surface of invasive tumor cells. Batimastat, marimastat and GM 6001 are hydroxamate compounds that chelate the catalytic zinc and inhibit a wide range of MMPs. More selective tools include NSC 405020 for MT1-MMP and T-26c for MMP-13. Metalloproteases of the related ADAM family are listed in the neighboring ADAMs category.
