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Prolyl Endopeptidase (PREP)

Prolyl endopeptidase (PREP) inhibitors target a serine protease that cuts short peptides after proline. The cytosolic enzyme is also known in the literature as prolyl oligopeptidase (POP). A seven-bladed beta-propeller domain covers the catalytic site and admits only peptides of about 30 residues or fewer. Reported substrates include neuropeptides such as substance P, arginine vasopressin and thyrotropin-releasing hormone. PREP also binds alpha-synuclein, and KYP-2047 lowers alpha-synuclein aggregates in cell and mouse models of Parkinson's disease. Next to inhibitors such as KYP-2047, Y-29794 oxalate and SUAM 1221, the section lists the chromogenic p-nitroanilide (pNA) substrates Z-Gly-Pro-pNA and Suc-Ala-Pro-pNA for activity assays.

2 Items

  • Suc-Ala-Pro-pNA
    Cat. No.
    A77266
    CAS No.
    95632-46-5

    Suc-Ala-Pro-pNA

    Suc-Ala-Pro-pNA is a specific substrate for prolyl endopeptidase (PEP), designed to facilitate the measurement of PEP activity and stability. This peptide substrate releases para-nitroaniline (pNA) upon hydrolysis, enabling quantification in various experimental settings. It is valuable for biochemical assays and research focused on proteolytic enzyme activity, particularly in the context of neurodegenerative diseases and other related disorders.

    In stock View Details
    5 mg
    $55.00
    10 mg
    $90.00
    All 2 sizes
  • Z-Gly-Pro-pNA
    Cat. No.
    A77268
    CAS No.
    65022-15-3

    Z-Gly-Pro-pNA

    Z-Gly-Pro-pNA is a substrate designed for the assessment of prolyl endopeptidase (PEP) activity. This compound can be utilized in assays to quantify PEP inhibition, offering insights into enzymatic function and regulation. It serves as an important tool for researchers investigating the role of PEP in various biological processes and potential therapeutic targets.

    In stock View Details
    25 mg
    $30.00
    50 mg
    $50.00
    All 3 sizes

2 Items

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