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Protein Tyrosine Phosphatase

Protein tyrosine phosphatase (PTP) inhibitors block enzymes that remove phosphate groups from tyrosine residues. PTPs counterbalance tyrosine kinases, and the classical PTPs share a catalytic cysteine within a conserved active-site motif. Mice lacking PTP1B show increased insulin sensitivity, which made this enzyme a model target in metabolic signaling research. SHP099 and SHP394 are allosteric inhibitors of Src homology 2 domain-containing phosphatase 2 (SHP2), which relays signals from receptor tyrosine kinases. NSC 87877 acts at the catalytic sites of SHP1 and SHP2, and TCS 401 free base inhibits PTP1B. Alexidine dihydrochloride inhibits PTP localized to the mitochondrion 1 (PTPMT1), a phosphatase located in the inner mitochondrial membrane.

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  • PTPN2/1-IN-2
    Cat. No.
    A36251
    CAS No.
    2407611-02-1

    PTPN2/1-IN-2

    PTPN2/1-IN-2 is a selective antagonist of PTPN2 and PTPN1, which are protein tyrosine phosphatases involved in regulating cellular signaling pathways. This compound has demonstrated potential in modulating tumor growth and immune responses, making it valuable for cancer research. PTPN2/1-IN-2 can be utilized to study the role of these phosphatases in cancer progression and to explore therapeutic strategies targeting these enzymes.

    In stock View Details
    1 mg
    $425.00
    5 mg
    $1,100.00
    All 3 sizes

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