- Cat. No.
- A17165
UK-371804
UK-371804 is a potent urokinase-type plasminogen activator (uPA) inhibitor.
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Urokinase inhibitors target urokinase-type plasminogen activator (uPA), a serine protease that generates plasmin. uPA is secreted as a single-chain proenzyme and binds a glycolipid-anchored receptor, the uPA receptor (uPAR). The receptor was cloned in 1990 and concentrates plasminogen activation at the cell surface. Plasmin degrades extracellular matrix proteins and activates latent growth factors, linking the system to cell migration and tumor invasion. uPAR also signals through integrins and other membrane partners, independent of proteolysis. Small-molecule uPA inhibitors include 4-Chlorophenylguanidine hydrochloride, BC 11 hydrobromide and ZK824190. GGACK Dihydrochloride is a peptide chloromethyl ketone that inactivates the protease irreversibly. Cenupatide differs from the others because it acts on uPAR rather than the enzyme.
UK-371804 is a potent urokinase-type plasminogen activator (uPA) inhibitor.
ZK824859 is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.
Synonyms: UK371804
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.
Glutaryl-Gly-Arg-AMC is a specific peptide substrate for urokinase plasminogen activator (uPA). This compound is utilized in biochemical assays to measure uPA activity, making it a valuable tool in research focused on cancer metastasis and tissue remodeling processes. Its fluorescent properties allow for sensitive detection and quantification of uPA activity in various biological samples.
UK-356202 is a potent urokinase-type plasminogen activator (uPA) inhibitor, exhibiting a Ki value of 0.037 μM. This compound plays a significant role in modulating fibrinolysis and cellular processes associated with wound healing. Its primary applications include research focused on the topical treatment of chronic ulcerous wounds, providing insights into therapeutic strategies for enhancing tissue repair and regeneration.