Fig. 1 · Structure
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Prothionamide
Anti-tuberculosis Agent
Prothionamide is an orally active thioamide compound that serves as an effective anti-tuberculosis agent by targeting Mycobacterium tuberculosis and Mycobacterium leprae. It acts as a substrate for OCT1 and forms a covalent adduct with NAD, serving as a potent inhibitor of the enzyme InhA. Prothionamide demonstrates significant antibacterial activity against Mycobacterium tuberculosis, with a minimum inhibitory concentration (MIC) of approximately 0.5 µg/mL. This reagent is valuable for scientific research focused on tuberculosis and leprosy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 14222-60-7 |
| Applications | Anti-tuberculosis Agent |
| Formula | C9H12N2S |
| Molecular Weight | 180.28 |
| Synonyms | Protionamide |
| SMILES | S=C(C1=CC(CCC)=NC=C1)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.