PRT543 (PRMT5-IN-35) is a potent, selective, and orally active inhibitor of protein arginine methyltransferase 5 (PRMT5), with an IC₅₀ value of 1 nM. It effectively targets PRMT5-mediated epigenetic regulation and demonstrates strong potential for use in cancer research, particularly in malignancies driven by dysregulated arginine methylation.
PRT543 (PRMT5-IN-35) is a potent, selective, and orally active inhibitor of protein arginine methyltransferase 5 (PRMT5), with an IC₅₀ value of 1 nM. It effectively targets PRMT5-mediated epigenetic regulation and demonstrates strong potential for use in cancer research, particularly in malignancies driven by dysregulated arginine methylation.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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