Fig. 1 · Structure
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Pyrocoll
Anticancer Agent
Pyrocoll is a bacterial metabolite derived from Streptomyces, functioning primarily as an anticancer agent. It exhibits significant inhibitory effects on various bacterial strains, including A. aurescens, A. globiformis, A. oxydans, A. pascens, and R. erythropolis, with minimum inhibitory concentrations ranging from 1 to 10 μg/mL. In cancer research, Pyrocoll demonstrates potent growth inhibition of HepG2, MCF-7, and HMO2 cell lines, with GI50 values of 0.28, 0.42, and 2.2 μg/mL, respectively. Additionally, it displays antimalarial and anti-trypanosomal activity, with IC50 values of 1.19 and 1.97 μg/mL against P. falciparum and T. rhodesiense, respectively.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 484-73-1 |
| Applications | Anticancer Agent |
| Formula | C10H6N2O2 |
| Molecular Weight | 186.17 |
| SMILES | O=C(C1=CC=CN1C2=O)N3C2=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.