(R)-8-Azido-2-(Fmoc-amino)octanoic acid is a non-cleavable linker for antibody-drug conjugates (ADCs), facilitating the synthesis of targeted therapeutics. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with entities that possess DBCO or BCN functionalities, making it a versatile tool in chemical biology and medicinal chemistry applications.
(R)-8-Azido-2-(Fmoc-amino)octanoic acid is a non-cleavable linker for antibody-drug conjugates (ADCs), facilitating the synthesis of targeted therapeutics. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with entities that possess DBCO or BCN functionalities, making it a versatile tool in chemical biology and medicinal chemistry applications.
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