Fig. 1 · Structure
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(R)-GSK 2830371
R-enantiomer of GSK 2830371
(R)-GSK 2830371 is the R-enantiomer of GSK 2830371, designed to selectively inhibit the Wip1 phosphatase with an IC50 of 6 nM. This compound plays a critical role in regulating signaling pathways involved in cellular responses to stress and DNA damage. Its selective inhibition makes it a valuable tool for research applications in cancer biology and cell cycle regulation, providing insights into therapeutic strategies targeting Wip1-associated pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2743427-27-0 |
| Applications | R-enantiomer of GSK 2830371 |
| Formula | C23H29ClN4O2S |
| Molecular Weight | 461.02 |
| SMILES | ClC1=CN=C(C)C(NCC2=CC=C(C(N[C@H](CC3CCCC3)C(NC4CC4)=O)=O)S2)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.