(R)-JAK2/STAT3-IN-1 is a selective inhibitor of the GP130 D1 domain, primarily targeting the JAK2/STAT3 signaling pathway. This compound demonstrates significant anti-tumor activity by inhibiting the phosphorylation of JAK2 and STAT3, thereby impairing tumor cell viability and migration while promoting apoptosis. With an affinity of 3.8 μM for GP130, (R)-JAK2/STAT3-IN-1 serves as a valuable tool for research into cancer biology and therapeutic interventions.
(R)-JAK2/STAT3-IN-1 is a selective inhibitor of the GP130 D1 domain, primarily targeting the JAK2/STAT3 signaling pathway. This compound demonstrates significant anti-tumor activity by inhibiting the phosphorylation of JAK2 and STAT3, thereby impairing tumor cell viability and migration while promoting apoptosis. With an affinity of 3.8 μM for GP130, (R)-JAK2/STAT3-IN-1 serves as a valuable tool for research into cancer biology and therapeutic interventions.
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