We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

Trk Receptors

Trk receptor inhibitors act on tropomyosin receptor kinases (Trk), the receptor tyrosine kinases for neurotrophins. Tropomyosin receptor kinases A, B and C (TrkA, TrkB, TrkC) are encoded by the neurotrophic receptor tyrosine kinase genes (NTRK1, NTRK2, NTRK3). In 1991 TrkA was identified as a signal-transducing receptor for nerve growth factor (NGF). In the same year TrkB was shown to bind brain-derived neurotrophic factor (BDNF) and neurotrophin-3. The receptors support neuronal survival and synaptic plasticity, and NTRK1-3 gene fusions are studied in several tumor types. Entrectinib inhibits all three Trk receptors together with c-ros oncogene 1 (ROS1) and anaplastic lymphoma kinase (ALK). AZ 23 targets TrkA and TrkB, whereas ANA-12 is a TrkB inhibitor used to probe BDNF signaling.

4 Items

  • ANA-12
    Cat. No.
    A13877
    CAS No.
    219766-25-3

    ANA-12

    ANA-12 is a TrkB receptor antagonist that demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively.

    In stock View Details
    1 mg
    $25.00
    2 mg
    $40.00
    All 8 sizes
  • LM11A-31 HCl
    Cat. No.
    A22564
    CAS No.
    1243259-19-9

    LM11A-31 HCl

    Synonyms: LM11A-31 hydrochloride; LM11A-31

    LM11A-31 is a small-molecule p75NTR modulator and proNGF antagonist.

    In stock View Details
    5 mg
    $20.00
    10 mg
    $30.00
    All 7 sizes
  • ALE-0540
    Cat. No.
    A34983
    CAS No.
    234779-34-1

    ALE-0540

    ALE-0540 is a nonpeptidic small molecule that acts as an antagonist of the nerve growth factor receptor. It effectively inhibits the binding of nerve growth factor (NGF) to the receptor tyrosine kinase A (TrkA) and the p75 neurotrophin receptor, with IC50 values of 5.88 μM and 3.72 μM, respectively. This compound is valuable for investigating the underlying mechanisms of pain and developing new therapeutic agents targeting pain pathways.

    In stock View Details
    5 mg
    $30.00
    10 mg
    $45.00
    All 6 sizes
  • Pegcantratinib
    Cat. No.
    A35012
    CAS No.
    1233363-33-1

    Pegcantratinib

    Synonyms: CT327; SNA-120

    Pegcantratinib is a selective TRKA antagonist that also exhibits activity against TRKB and TRKC. This compound is valuable for research into CYLD cutaneous syndrome (CCS) and inflammatory dermatoses, including psoriasis and associated pruritus. Its targeted inhibition of TRK receptors makes it a promising tool for studying the underlying mechanisms of these conditions.

    In stock View Details
    25 mg
    $2,035.00
    50 mg
    $2,610.00
    All 3 sizes

4 Items

Added to your cart

View Cart Checkout

    Loading...