Regorafénib N-oxyde (M2)-13C,d3 is a stable isotope-labeled derivative of Regorafénib N-oxyde (M2), which is an active metabolite of the multi-targeted kinase inhibitor Regorafenib. This compound primarily exerts its biological activity by inhibiting vascular endothelial growth factor receptors (VEGFR1/2/3), platelet-derived growth factor receptor beta (PDGFRβ), and other key oncogenic drivers, thereby affecting cellular proliferation and survival pathways. Regorafénib's inhibition profile includes IC50 values of 13, 4.2, 46, 22, 7, 1.5, and 2.5 nM for its various targets, making it a valuable tool in cancer research and therapeutic studies.
Regorafénib N-oxyde (M2)-13C,d3 is a stable isotope-labeled derivative of Regorafénib N-oxyde (M2), which is an active metabolite of the multi-targeted kinase inhibitor Regorafenib. This compound primarily exerts its biological activity by inhibiting vascular endothelial growth factor receptors (VEGFR1/2/3), platelet-derived growth factor receptor beta (PDGFRβ), and other key oncogenic drivers, thereby affecting cellular proliferation and survival pathways. Regorafénib's inhibition profile includes IC50 values of 13, 4.2, 46, 22, 7, 1.5, and 2.5 nM for its various targets, making it a valuable tool in cancer research and therapeutic studies.
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