RG-239 is a selective TGR5 agonist with an EC50 of 120 nM, exhibiting superior potency compared to Betulinic acid (EC50 = 1.04 μM). It enhances mitochondrial activity in adipocytes and promotes neurite outgrowth at elevated concentrations. Additionally, RG-239 effectively inhibits LPS-induced iNOS expression and nitrite production in Raw264.7 macrophages and microglial cells. This compound is valuable for studies related to type 2 diabetes and neurodegenerative disorders.
RG-239 is a selective TGR5 agonist with an EC50 of 120 nM, exhibiting superior potency compared to Betulinic acid (EC50 = 1.04 μM). It enhances mitochondrial activity in adipocytes and promotes neurite outgrowth at elevated concentrations. Additionally, RG-239 effectively inhibits LPS-induced iNOS expression and nitrite production in Raw264.7 macrophages and microglial cells. This compound is valuable for studies related to type 2 diabetes and neurodegenerative disorders.
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