RIPK1-IN-19 is a selective inhibitor of receptor-interacting protein kinase 1 (RIPK1), exhibiting an IC50 of 15 nM. It demonstrates significant protective effects in models of systemic inflammatory response syndrome (SIRS) induced by TNFα, as well as in imiquimod-induced psoriasis models. This compound serves as a valuable tool for investigating the roles of RIPK1 in inflammation and immune system disorders.
RIPK1-IN-19 is a selective inhibitor of receptor-interacting protein kinase 1 (RIPK1), exhibiting an IC50 of 15 nM. It demonstrates significant protective effects in models of systemic inflammatory response syndrome (SIRS) induced by TNFα, as well as in imiquimod-induced psoriasis models. This compound serves as a valuable tool for investigating the roles of RIPK1 in inflammation and immune system disorders.
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