RIPK1-IN-20 is a potent inhibitor targeting RIPK1 kinase, exhibiting significant enzymatic inhibition with an IC50 value of 59.8 nM. This compound effectively blocks TNFα-induced necroptosis in both human and murine cells, demonstrating EC50 values ranging from 1.06 to 4.58 nM. It serves as a valuable tool for research into cell death pathways and therapeutic interventions in necroptotic diseases.
RIPK1-IN-20 is a potent inhibitor targeting RIPK1 kinase, exhibiting significant enzymatic inhibition with an IC50 value of 59.8 nM. This compound effectively blocks TNFα-induced necroptosis in both human and murine cells, demonstrating EC50 values ranging from 1.06 to 4.58 nM. It serves as a valuable tool for research into cell death pathways and therapeutic interventions in necroptotic diseases.
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