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Roflumilast

Catalog No.: A10804

PDE inhibitor

Roflumilast

Roflumilast Chemical Structure

CAS NO. 162401-32-3

Roflumilast acts as a selective, long-acting inhibitor of the enzyme PDE-4.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $40.00

Special Price $32.00

10 mg

Regular Price: $65.00

Special Price $52.00

50 mg

Regular Price: $180.00

Special Price $144.00

100 mg

Regular Price: $300.00

Special Price $240.00

10mM * 1mL in DMSO

Regular Price: $65.00

Special Price $52.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Zhongyuan Zhang, .et al. Roflumilast, a type of phosphodiesterase 4 inhibitor, can reduce intestinal injury caused by sepsis, Exp Ther Med, 2021, Dec;22(6):1398 PMID: 34650646
  • Bing Zhong, .et al. Roflumilast Reduced the IL-18-Induced Inflammatory Response in Fibroblast-Like Synoviocytes (FLS), ACS Omega, 2021, Jan 26; 6(3): 2149-2155 PMID: 33521454

Biological Activity

Roflumilast acts as a selective, long-acting inhibitor of the enzyme PDE-4.
Targets
Target Value
PDE4B2IC50: 0.2nM
PDE4A1IC50: 0.7nM
PDE4B1IC50: 0.7nM
PDE4A4IC50: 0.9nM
PDE4C1IC50: 3nM
PDE4C2IC50: 4.3nM
In vitro (25°C) DMSO 70 mg/mL (173.6 mM)
Water Insoluble
Ethanol 13 mg/mL (32.24 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.8 mL 124.01 mL 248.02 mL
0.5 mM 4.96 mL 24.8 mL 49.6 mL
1 mM 2.48 mL 12.4 mL 24.8 mL
5 mM 0.5 mL 2.48 mL 4.96 mL

*The above data is based on the productmolecular weight 403.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10804
Actions Inhibitor
CAS No. 162401-32-3
Formula C17H14Cl2F2N2O3
M. Wt 403.2
Purity >98%
Synonyms Daxas, Daliresp
SMILES C1CC1COC2=C(C=CC(=C2)C(=O)NC3=C(C=NC=C3Cl)Cl)OC(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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