RSL3
RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS.
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Adooq Products cited in reputable paper
Adooq's RSL3 has been cited by 9 publications
- Cheng Chen, .et al. , Neurochem Res, 2025, Mar 18;50(2):122 PMID: 40100474
- Xiaona Cao, .et al. , J Nanobiotechnology, 2025, Feb 24;23(1):136 PMID: 39994619
- Naoya Yamada, .et al. , Nat Commun, 2024, 15:2195
- Ning Li, .et al. , J Ovarian Res, 2024, Feb 23;17(1):49 PMID: 38396022
- Yuki Kojima, .et al. , Journal of Gastroenterology, 2023, Nov 10
- Qingyu Zhang, .et al. , Cell Death Discov, 2023, Mar 8;9(1):83 PMID: 36882396
- Sampilvanjil A, .et al. , Am J Physiol Heart Circ Physiol, 2020, Mar 1;318(3):H508-H518 PMID: 31975626
- Fujiki K, .et al. , Cell Death Differ, 2019, Feb 25 PMID: 30804470
- Samantha W. Alvarez, .et al. , Nature, 2017, Nov 30; 551(7682): 639-643 PMID: 29168506
Biological Activity
| Description | RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. | |||||
|---|---|---|---|---|---|---|
| Targets |
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| Cell Research |
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Product Information
| Catalog Num | A15865 |
|---|---|
| Formula | C23H21ClN2O5 |
| Molecular Weight | 440.88 |
| CAS Number | 1219810-16-8 |
| SMILES | COC(C1=CC=C([C@@]2([H])C3=C(C4=CC=CC=C4N3)C[C@](N2C(CCl)=O)([H])C(OC)=O)C=C1)=O |
| Synonyms | 1S,3R-RSL3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro (25°C) | DMSO | 82 mg/mL (185.99 mM) | |
| Water | Insoluble | ||
| Ethanol | 20 mg/mL | ||
| In vivo | 2% DMSO+30% PEG 300+2% Tween 80+ddH2O | 1 mg/mL | |
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.68 mL | 113.41 mL | 226.82 mL |
| 0.5 mM | 4.54 mL | 22.68 mL | 45.36 mL |
| 1 mM | 2.27 mL | 11.34 mL | 22.68 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
