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$0.00 - Sampilvanjil A, .et al. Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells, Am J Physiol Heart Circ Physiol, 2020, Mar 1;318(3):H508-H518 PMID: 31975626
- Fujiki K, .et al. Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms, Cell Death Differ, 2019, Feb 25 PMID: 30804470
- Samantha W. Alvarez, .et al. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis, Nature, 2017, Nov 30; 551(7682): 639-643 PMID: 29168506
Biological Activity
RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS.
Targets
| Gpx4 | ||||
| In vitro (25°C) | DMSO | 82 mg/mL (185.99 mM) | |
| Water | Insoluble | ||
| Ethanol | 20 mg/mL | ||
| In vivo | 2% DMSO+30% PEG 300+2% Tween 80+ddH2O | 1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.68 mL | 113.41 mL | 226.82 mL |
| 0.5 mM | 4.54 mL | 22.68 mL | 45.36 mL |
| 1 mM | 2.27 mL | 11.34 mL | 22.68 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
*The above data is based on the productmolecular weight 440.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15865 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1219810-16-8 |
| Formula | C23H21ClN2O5 |
| M. Wt | 440.88 |
| Purity | >98% |
| Synonyms | 1S,3R-RSL3 |
| SMILES | COC(C1=CC=C([[email protected]@]2([H])C3=C(C4=CC=CC=C4N3)C[[email protected]](N2C(CCl)=O)([H])C(OC)=O)C=C1)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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