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(RXR)4XB

Catalog No.: A50072
Cell-Penetrating Peptide
(RXR)4XB is a cell-penetrating peptide designed to enhance the delivery of phosphorodiamidate morpholino oligomers (PMOs) into bacterial cells. This peptide-conjugated PMO (PPMO) effectively disrupts biofilm formation and demonstrates potent antimicrobial activity against Pseudomonas aeruginosa, with an MIC50 ranging from 0.5 to 16 μM. Additionally, (RXR)4XB-PMO conjugates have shown significant efficacy in reducing bacterial burden in mouse models of acute pneumonia, making them valuable tools for studying bacterial infections and therapeutic interventions.
(RXR)4XB 879010-15-8 Cell-Penetrating Peptide
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description(RXR)4XB is a cell-penetrating peptide designed to enhance the delivery of phosphorodiamidate morpholino oligomers (PMOs) into bacterial cells. This peptide-conjugated PMO (PPMO) effectively disrupts biofilm formation and demonstrates potent antimicrobial activity against Pseudomonas aeruginosa, with an MIC50 ranging from 0.5 to 16 μM. Additionally, (RXR)4XB-PMO conjugates have shown significant efficacy in reducing bacterial burden in mouse models of acute pneumonia, making them valuable tools for studying bacterial infections and therapeutic interventions.
Product Information
Catalog NumA50072
FormulaC81H158N38O15
Molecular Weight1904.37
CAS Number879010-15-8
SequenceArg-{Ahx}-Arg-Arg-{Ahx}-Arg-Arg-{Ahx}-Arg-Arg-{Ahx}-Arg-{Ahx-βAla}
Sequence shorteningR-{Ahx}-RR-{Ahx}-RR-{Ahx}-RR-{Ahx}-R-{Ahx-βAla}
SMILES[C@@H](NC([C@@H](NC(CCCCCNC([C@@H](NC([C@@H](NC(CCCCCNC([C@H](CCCNC(=N)N)N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N)=O)(C(NCCCCCC(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(NCCCCCC(NCCC(O)=O)=O)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N
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