S 1360 is a potent and selective inhibitor of HIV-1 integrase, effectively disrupting its catalytic activity with an IC50 of 20 nM. This compound exhibits antiviral activity against both X4 and R5 tropic strains of HIV-1, including variants resistant to NRTIs, NNRTIs, and PIs. In MTT assays using HIV-1 IIIB-infected MT-4 cells, S 1360 shows an EC50 of 200 nM and a CC50 of 12 μM, making it a valuable reagent for research in HIV-1 treatment and resistance mechanisms.
S 1360 is a potent and selective inhibitor of HIV-1 integrase, effectively disrupting its catalytic activity with an IC50 of 20 nM. This compound exhibits antiviral activity against both X4 and R5 tropic strains of HIV-1, including variants resistant to NRTIs, NNRTIs, and PIs. In MTT assays using HIV-1 IIIB-infected MT-4 cells, S 1360 shows an EC50 of 200 nM and a CC50 of 12 μM, making it a valuable reagent for research in HIV-1 treatment and resistance mechanisms.
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