Fig. 1 · Structure
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(S)-GSK-3685032
Isomer
(S)-GSK-3685032 is the isomer of GSK-3685032 and serves as an experimental control in research settings. This compound is a first-in-class reversible inhibitor selective for DNA methyltransferase 1 (DNMT1), exhibiting a potent IC50 value of 0.036 μM. (S)-GSK-3685032 effectively induces a significant reduction in DNA methylation, leading to transcriptional activation and inhibition of cancer cell proliferation. It is utilized in studies focused on epigenetic modulation and cancer therapy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2170142-58-0 |
| Applications | Isomer |
| Formula | C22H24N6OS |
| Molecular Weight | 420.53 |
| SMILES | N#CC1=C(N2CCC(CC2)N)N=C(C(C#N)=C1CC)S[C@@H](C3=CC=CC=C3)C(N)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.