(S)-O12-D3-I3

Catalog No.: A76291
Liposome
(S)-O12-D3-I3 is an ionizable cationic lipid with a pKa of 6.39. It is primarily utilized for the formulation of lipid nanoparticles (LNPs), facilitating effective siRNA delivery for both in vitro and in vivo applications. This compound is particularly valuable in cancer research, including studies focused on liver and breast cancer, where targeted gene silencing is essential for therapeutic investigations.
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5mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description(S)-O12-D3-I3 is an ionizable cationic lipid with a pKa of 6.39. It is primarily utilized for the formulation of lipid nanoparticles (LNPs), facilitating effective siRNA delivery for both in vitro and in vivo applications. This compound is particularly valuable in cancer research, including studies focused on liver and breast cancer, where targeted gene silencing is essential for therapeutic investigations.
Product Information
Catalog NumA76291
FormulaC39H73N5O5
Molecular Weight692.04
CAS Number3041009-08-6
SMILESC([C@@H](C(NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)=O)N)C1=CN=CN1
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