Fig. 1 · Structure
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S1RA hydrochloride
σ1R Antagonist
S1RA hydrochloride is a selective antagonist of the sigma-1 receptor (σ1R), exhibiting a Ki value of 17 nM and demonstrating high selectivity against the σ2 receptor (Ki >1000 nM). In addition, it acts as a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride has been shown to inhibit neuropathic pain and modulate activity-induced spinal sensitization, making it a valuable tool for research in pain mechanisms and pharmacological interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1265917-14-3 |
| Applications | σ1R Antagonist |
| Formula | C20H24ClN3O2 |
| Molecular Weight | 373.88 |
| Synonyms | E-52862 hydrochloride |
| SMILES | CC1=CC(OCCN2CCOCC2)=NN1C3=CC(C=CC=C4)=C4C=C3.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.