Salmeterol-d3 is a deuterated form of Salmeterol, acting as a selective agonist for the human β2 adrenergic receptor. This compound effectively stimulates cyclic AMP (cAMP) accumulation in Chinese Hamster Ovary (CHO) cells expressing human β2 adrenergic receptors, demonstrating a pEC50 of 9.6, along with lower activity at β1 and β3 adrenergic receptors (pEC50 values of 6.1 and 5.9, respectively). Salmeterol-d3 is valuable for research applications focused on respiratory diseases, drug metabolism studies, and the pharmacological profiling of β2 agonists.
Salmeterol-d3 is a deuterated form of Salmeterol, acting as a selective agonist for the human β2 adrenergic receptor. This compound effectively stimulates cyclic AMP (cAMP) accumulation in Chinese Hamster Ovary (CHO) cells expressing human β2 adrenergic receptors, demonstrating a pEC50 of 9.6, along with lower activity at β1 and β3 adrenergic receptors (pEC50 values of 6.1 and 5.9, respectively). Salmeterol-d3 is valuable for research applications focused on respiratory diseases, drug metabolism studies, and the pharmacological profiling of β2 agonists.
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