SARS-CoV-2 3CLpro-IN-18 is a covalent inhibitor targeting the SARS-CoV-2 3CL protease, with an IC50 of 0.478 μM. This compound exhibits antiviral activity against SARS-CoV-2 in Vero E6 cells, demonstrating an EC50 of 2.499 μM, while maintaining low cytotoxicity (CC50 > 200 μM). It serves as a valuable tool for research on SARS-CoV-2 inhibition and the development of therapeutic strategies against COVID-19.
SARS-CoV-2 3CLpro-IN-18 is a covalent inhibitor targeting the SARS-CoV-2 3CL protease, with an IC50 of 0.478 μM. This compound exhibits antiviral activity against SARS-CoV-2 in Vero E6 cells, demonstrating an EC50 of 2.499 μM, while maintaining low cytotoxicity (CC50 > 200 μM). It serves as a valuable tool for research on SARS-CoV-2 inhibition and the development of therapeutic strategies against COVID-19.
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