SARS-CoV-IN-4

Catalog No.: A53389
SARS-CoV nsp14 Inhibitor
SARS-CoV-IN-4 is a potent inhibitor of the SARS-CoV nsp14 N7-methyltransferase, with an IC50 of 0.6 μM. This compound offers specificity in targeting the N7-methyltransferase activity, making it a valuable tool for studying viral RNA modification processes. SARS-CoV-IN-4 is relevant for research applications related to antiviral drug discovery and the mechanistic understanding of SARS-CoV replication and pathogenesis.
Grouped product items
Size Stock
5mg
10mg
50mg
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSARS-CoV-IN-4 is a potent inhibitor of the SARS-CoV nsp14 N7-methyltransferase, with an IC50 of 0.6 μM. This compound offers specificity in targeting the N7-methyltransferase activity, making it a valuable tool for studying viral RNA modification processes. SARS-CoV-IN-4 is relevant for research applications related to antiviral drug discovery and the mechanistic understanding of SARS-CoV replication and pathogenesis.
Product Information
Catalog NumA53389
FormulaC28H31ClN12O11S
Molecular Weight779.14
CAS Number2445585-37-3
SMILESO[C@H]([C@@H]1O)[C@@](N2C3=NC=NC(N)=C3N=C2)([H])O[C@@H]1CN(S(=O)(C4=CC([N+]([O-])=O)=C(C=C4)Cl)=O)CCO[C@H]5[C@](O[C@@H]([C@H]5O)CO)([H])N6C7=NC=NC(N)=C7N=C6
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