Fig. 1 · Structure
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SB 243213 dihydrochloride
5-HT2C Receptor Antagonist
SB 243213 dihydrochloride is a selective and high-affinity antagonist of the 5-HT2C receptor, exhibiting a pKi of 9.37 and a pKb of 9.8 for the human 5-HT2C receptor. This compound displays over 100-fold selectivity for the 5-HT2C receptor relative to various neurotransmitter receptors, enzymes, and ion channels. SB 243213 dihydrochloride is noted for its improved anxiolytic profile and holds potential for therapeutic applications in schizophrenia and motor disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1780372-25-9 |
| Applications | 5-HT2C Receptor Antagonist |
| Formula | C22H21Cl2F3N4O2 |
| Molecular Weight | 501.33 |
| SMILES | O=C(N1CCC2=C1C=C(C(F)(F)F)C(C)=C2)NC3=CC=C(OC4=CC=CN=C4C)N=C3.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.