Fig. 1 · Structure
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Schisandrone
MRSA Inhibitor
Schisandrone is a 4-aryltetralone lignan that functions as a potent MRSA inhibitor through its action as an alpha-hemolysin (Hla) inhibitor. By downregulating the transcript levels of hla, agrA, and RNAIII, Schisandrone interferes with key virulence factors of Staphylococcus aureus, which is crucial for its pathogenicity. This compound has demonstrated significant efficacy in combating MRSA pneumonia, making it a valuable reagent for research in antimicrobial therapies and infections.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 98619-25-1 |
| Applications | MRSA Inhibitor |
| Formula | C21H24O5 |
| Molecular Weight | 356.41 |
| SMILES | O=C1[C@@H](C)[C@@H](C)[C@H](C2=CC=C(OC)C(OC)=C2)C3=C1C=C(O)C(OC)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.