SJ1461 is a potent BET inhibitor that selectively targets bromodomain-containing proteins BRD2 and BRD4. It demonstrates high affinity with IC50 values of 1.6 nM for BRD2 (BD1), 0.1 nM for BRD2 (BD2), 6.5 nM for BRD4 (BD1), and 0.2 nM for BRD4 (BD2). SJ1461 is utilized in research applications related to cancer, inflammation, and epigenetic regulation, making it a valuable tool for investigating the role of BET proteins in various biological processes.
SJ1461 is a potent BET inhibitor that selectively targets bromodomain-containing proteins BRD2 and BRD4. It demonstrates high affinity with IC50 values of 1.6 nM for BRD2 (BD1), 0.1 nM for BRD2 (BD2), 6.5 nM for BRD4 (BD1), and 0.2 nM for BRD4 (BD2). SJ1461 is utilized in research applications related to cancer, inflammation, and epigenetic regulation, making it a valuable tool for investigating the role of BET proteins in various biological processes.
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