Fig. 1 · Structure
Documents & Downloads
SL44
ClpP Agonist
SL44 is a potent agonist of human caseinolytic protease P (HsClpP), demonstrating an EC50 of 1.30 μM. It effectively inhibits LM3 cell proliferation with an IC50 of 3.1 μM and induces apoptosis in hepatocellular carcinoma (HCC) cells by promoting the degradation of respiratory chain complex subunits. In vivo studies indicate SL44 exhibits significant antitumor efficacy in mouse models while maintaining a favorable safety profile (LD50=400 mg/kg). Additionally, SL44 shows promising pharmacokinetic properties in rat models, making it a valuable tool for cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 3054715-45-3 |
| Applications | ClpP Agonist |
| Formula | C22H20ClFN4O |
| Molecular Weight | 410.87 |
| SMILES | ClC1=C(F)C=CC(CC2=NOC(C3CCN(CC4=CC=CC(C#N)=C4)CC3)=N2)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.