SLM6031434 is a selective inhibitor of sphingosine kinase 2 (SphK2) with an IC50 value of 0.4 μM. This compound promotes sphingosine accumulation and enhances Smad7 expression, leading to anti-fibrotic effects. SLM6031434 has demonstrated significant efficacy in reducing tubulointerstitial fibrosis in a mouse model of unilateral ureteral obstruction (UUO). It serves as a valuable tool for investigating proteinuric kidney diseases and chronic kidney disease (CKD).
SLM6031434 is a selective inhibitor of sphingosine kinase 2 (SphK2) with an IC50 value of 0.4 μM. This compound promotes sphingosine accumulation and enhances Smad7 expression, leading to anti-fibrotic effects. SLM6031434 has demonstrated significant efficacy in reducing tubulointerstitial fibrosis in a mouse model of unilateral ureteral obstruction (UUO). It serves as a valuable tool for investigating proteinuric kidney diseases and chronic kidney disease (CKD).
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