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SNIPER(ABL)-039

Name: SNIPER(ABL)-039
Brand: Adooq Bioscience
SKU: A19588
Availability: OutOfStock

Cat. No. A19588 CAS 2222354-29-0

SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively.

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Biological Activity

Target & Activity

Target	Activity	Value
Abl	IC50	0.54 nM
cIAP1	IC50	10 nM
cIAP2	IC50	12 nM
XIAP	IC50	50 nM
SNIPER
Abl	DC50	10 nM

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2222354-29-0
Formula	C₅₄H₆₈ClN₁₁O₉S₂
Molecular Weight	1114.77
SMILES	CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(C(COCCOCCOCCOC5=CC(C(C6=CSC([C@H]7N(C([C@H](C8CCCCC8)NC([C@H](C)NC)=O)=O)CCC7)=N6)=O)=CC=C5)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.